Compiègne Lipidomique 5

8:30-8:45 Welcome to participants by the president of UTC and of the region

PLANT COMPOUND VALORIZATION

8:45-9:05 D. Thomas : Agroresources and the biorefinery concept (UMR-CNRS 6022, UTC, France)

9:05-9:30 G. Gosse : Biomass, oilseed crops, a renewable sources of energy and molecules. A key issue ? (INRA, Estrée-Mons, France)

SESSION 1 :

PRODUCTION OF LIPIDS AND BIODIVERSITY
(E. Gontier)

Existing biodiversity of oils and fatty acids, production systems for new profiles of fatty acids and oils to solve problems of limited fossil resources, of health (plants, algae, bacteria, fungi, yeast)

9:30-9:55 Gilles Barnathan : Non-methylene-interrupted fatty acids from marine organisms : occurrence, characterization and biological properties (Pôle Mer et Littoral, Laboratoire de Chimie Marine, Groupe SMAB (EA 2160), Substances marines à activité biologique, Université de Nantes, Fr)

9:55-10:25 John Harwood : Lipids and lipid metabolism in eukaryotic algae (Cardiff University, P.O. Box 911, Cardiff, UK)

10:25-11:05 Communications retained in submitted oral proposals

11:05- 11:20 Coffee break and Poster session

11:20-11:40 Anders Carlsson : A survey of the potentiality of plants to produce unusual fatty acids and oils (Swedish University of Agricultural Sciences, Alnarp, Sweden)

11:40-12:00 Ian Graham : Targeted metabolite profiling of fatty acids, acyl CoAs and triacylglycerols in oilseeds engineered to produce long chain polyunsaturated fatty acids (CNAP, Department of Biology, University of York, UK)

12:00-12:30 Communications retained in submitted oral proposals

12:30- 15:00 Lunch and Poster session

SESSION 2 :
LIPID METABOLISM – METHODS OF INVESTIGATIONS
(B. Thomasset)

Lipid metabolism and link to general metabolism (carbon, nitrogen, energy, ...) : genomic, proteomic and metabolomic tools, flux quantification (“fluxomics”) and predictive modeling (plants, microorganisms)

15:00-15:25 Jean-Charles Portais : Analysis of metabolic flexibility in microorganisms (Université de Toulouse, Toulouse, France)

15:25-15:50 George Ratcliffe : Measuring multiple fluxes through plant metabolic networks (Department of Plant Sciences, University of Oxford, UK)

15:50-16:10 Albrecht Roscher : Probing the metabolic consequences of modifications in fatty acid synthesis pathways in Brassica napus (Université de Picardie Jules Verne, Amiens, France)

16:10-16:25 Communications retained in submitted oral proposals

16:25- 16:45 Coffee break and Poster session

16:45-17:10 Jeroen Wilmer : Understanding lipid accumulation in developing Brassica seed – a transcriptome approach (BIOGEMMA, France)

17:10-17:35 Michel Rossignol : Proteomic studies as useful approaches toward the understanding of metabolic pathways : an example of investigation into the plant lipid metabolism (Plateforme de Protéomique, Toulouse, France)

17:35-18:20 Communications retained in submitted oral proposals

18:30 Welcome buffet Theater/Town Hall

Fatty acids transfer in membranes and triglyceride accumulation, lipid trafficking, mechanisms of accumulation (plants, microorganisms)

8:45-9:10 Ulf Stahl : A family of eukaryotic lysophospholipid acyltransferases with broad specificity (Dept. for Plant Biology and Forest Genetics, Swedish University for Agricultural Sciences, Uppsala, Sweden)

9:10-9:35 Frédéric Beisson : Hydroxy-fatty acids and dicarboxylic acids of the plant polymers cutin and suberin: diversity, biosynthesis and export into the cell wall (Michigan State University, East Lansing, USA)

SESSION 4 :
BIOMIMETIC MEMBRANES : BIOPHYSIC TOOLS TO CHARACTERIZE BIOMEMBRANES
(C. Sarazin, A. Girard-Egrot)

14:30-15:00 Christian Salesse : Lipid monolayers to monitor binding of proteins such as retinol dehydrogenase, retinitis pigmentosa 2 and lecithin retinol acyltransferase to membranes (Université Laval, Unité de Recherche en Ophtalmologie, Québec, Canada)

15:00-15:20 Thierry Granjon : Mitochondrial creatine kinase interaction with model membranes induces cardiolipin segregation and promotes protein domain movements (ICBMS/UMR 5246, Université Lyon 1, Villeurbanne, France)

15:40-16:05 Erick Dufourc : Biphenyl bicelles : a long lasting magnetically oriented biomembrane (UMR 5248 CBMN, Chimie et Biologie des Membranes et des Nanoobjets, Université Bordeaux 1, Pessac, France)

16:25-16:55 Göran Lindblom (Department of Chemistry, Umea University, Umea, Suède)

16:55-17:20 Bukhard Bechinger : What about solid-state NMR investigations of polypeptide-lipid interactions (Membrane Biophysics and NMR Chemistry, University Louis Pasteur, Strasbourg, France)

17:20-17:50 Bruno Antonny : Recognition of membrane curvature by ALPS motifs (UMR-CNRS 6097 - Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France)

17:50-18:05 Communications retained in submitted oral proposals

JEUDI 23 OCTOBRE

SESSION 5 :
FROM DISEASES TO PREVENTION
(M. Record, C. Forest, M. Lagarde, X. Collet)

Lipids and fatty acids are qualified as beneficial or dangerous for human health : nutritional aspects, pathological initiators, cardiovascular diseases, cholesterol, obesity and Cancers

8:45-9:10 Xavier Guillot : Plants producing Omega 3 fatty acids : specificities of the various vegetable sources, agro-environmental traits influencing their content (Laboulet Semences, Airaines, France)

9:10-9:35 Jean Dalongeville : Role of omega-3 fatty acids in prevention of cardiovascular diseases : epidemiological approach (Institut Pasteur, Lille, France)

9:35-10:00 Jean-Claude Mazière : Protective effect of n-3 polyunsaturated fatty acids against cardiovascular diseases: cellular and molecular aspects (CHU, Amiens, France)

10:45-11:10 Philippe Bougnoux : From breast cancer to prevention of distant relapses : rationale for an adjuvant dietary intervention based on DHA and CLA (INSERM U921 & Cancéropôle Grand ouest Centre Henry S. Kaplan, Tours, France)

11:10-11:35 Marc Poirot : Oxysterols (Institut Claudius Regaud, Toulouse, france)

16:30-16:55 Philippe Legrand : From alpha-linolenic fatty acids to DHA : the conversion pathway and its limits (INRA-Agrocampus Rennes)