Compiègne Lipidomique 5

7:45 Registration

8:30 Welcome to participants by the President of UTC, President of Region of Picardie, President of GERLI

PLANT COMPOUND VALORIZATION

8:55-9:15 D. Thomas : Agroresources and the biorefinery concept (UMR-CNRS 6022, UTC, France)

9:15-9:35 G. Gosse : Biomass, oil crops for energy and chemistry : Some key-questions (INRA, Estrée-Mons, France)

SESSION 1 :

PRODUCTION OF LIPIDS AND BIODIVERSITY
(E. Gontier and H. Schaller)

9:35-10:00 Gilles Barnathan : Non-methylene-interrupted fatty acids from marine organisms : occurrence, characterization and biological properties (Pôle Mer et Littoral, Laboratoire de Chimie Marine, Groupe SMAB (EA 2160), Substances marines à activité biologique, Université de Nantes, Fr)

10:00-10:15 Nicolas Ruiz : Detection of conjugated fatty acids produced by ascomycetes isolated from marine shellfish areas of the Loire estuary (Groupe SMAB, Université de Nantes, Nantes, France)

10:15-10:40 Anders Carlsson : A survey of the potential oil crop platforms for industrial uses (Swedish University of Agricultural Sciences, Alnarp, Sweden)

10:40-11:00 Coffee break and Poster session

11:05-11:30 John Harwood : Lipids and lipid metabolism in eukaryotic algae (Cardiff University, P.O. Box 911, Cardiff, UK)

11:30-11:45 J.J. Vermeire : Industrial ecosystem project (Eseta, Garches, France)

11:45-12:10 Ian Graham : Targeted metabolite profiling of fatty acids, acyl CoAs and triacylglycerols in oilseeds engineered to produce long chain polyunsaturated fatty acids (CNAP, Department of Biology, University of York, UK)

12:10-12:25 Narendra Yadav: Production of Omega-3 fatty acid from genetically engineered yeast Yarrowia lipolytica (DuPont Co, Wilmington, USA)

12:30- 15:00 Lunch and Poster session

SESSION 2 :
LIPID METABOLISM – METHODS OF INVESTIGATIONS
(B. Thomasset and I. Graham)

15:00-15:25 Jean-Charles Portais : Metabolic plasticity in micro-organisms: approaches and perspectives (Université de Toulouse, Toulouse, France)

15:25-15:40 J.M. Nicaud : Obesity in the yeast Yarrowia lipolytica: Model and tools (INRA AgroParisTech, Thiverval-Grignon, France)

15:40-16:05 George Ratcliffe : Measuring multiple fluxes through plant metabolic networks (Department of Plant Sciences, University of Oxford, UK)

16:05-16:25 Albrecht Roscher : Metabolic characterisation of transformed rapeseed embryos (Université de Picardie Jules Verne, Amiens, France)

16:25- 16:45 Coffee break and Poster session

16:45-17:10 Jeroen Wilmer : Understanding lipid accumulation in developing Brassica seed – a transcriptome approach (BIOGEMMA, France)

17:10-17:25 Madeleine Nlandu Mputu : Identification of Bottleneck in branched chain fatty acid incorporation into triacylglycerol for lipid biosynthesis in agronomic plants (UTC, Compiègne, France)

18:30 Welcome buffet to Town Hall

SESSION 2 :
LIPID METABOLISM – METHODS OF INVESTIGATIONS
(B. Thomasset)

8:45-9:00 Yong Hua Li : A member of an orphan family of cytochrome P450 monooxygenases is required for the synthesis of hydroxy fatty acids in plants (Michigan State University, Eats Lansing, USA)

9:00-9:15 Y. Igarashi : Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: Enzymatic basis for the preference of fatty acid chain length in cultured cell models (Saporro, Japan)

9:15-9:30 Cedric Desbène : Suppression of cytosolic PLA2 expression confers resistance to the synaptic dysfunctions and memory alterations induced by b- amyloid-peptide (ENSAIA-INPL, Vandoeuvre-lès-Nancy, France)

9:30-9:55 Frédéric Beisson : Hydroxy-fatty acids and dicarboxylic acids of the plant polymers cutin and suberin: diversity, biosynthesis and export into the cell wall (Michigan State University, East Lansing, USA)

9:55-10:10 José Graca : Multi-functional long chain fatty acids in suberins and cutins (Instituto superior de Agronomia, Lisboa, Portugal)

10:10-10:25 M.L. Lacombe : Mitochondrial NDP kinase-D binds to and cross- links membranes containing cardiolipin and couples nucleotide transfer with respiration (Faculté de Médecine Pierre et Marie Curie, Paris, France)

10:50-11:15 Banafshé Larijani : Role of polyphosphoinositides in nuclear envelope assembly (London Research Institute, London, UK)

SESSION 4 :
BIOMIMETIC MEMBRANES : BIOPHYSIC TOOLS TO CHARACTERIZE BIOMEMBRANES
(C. Sarazin, A. Girard-Egrot)

14:30-14:55 Christian Salesse : Lipid monolayers to monitor binding of proteins such as retinol dehydrogenase, retinitis pigmentosa 2 and lecithin retinol acyltransferase to membranes (Université Laval, Unité de Recherche en Ophtalmologie, Québec, Canada)

14:55-15:20 Thierry Granjon : Mitochondrial creatine kinase interaction with model membranes induces cardiolipin segregation and promotes protein domain movements (ICBMS/UMR 5246, Université Lyon 1, Villeurbanne, France)

15:20-15:40 S. Castano : Brewster angle microscopy and PMIRRAS study of DNA interactions with BGTC, a cationic lipid used for gene transfer (CBMN, Chimie et Biologie des Membranes et des Nano-objets, Université Bordeaux 1, Pessac, France)

15:40-16:00 Erick Dufourc : Biphenyl bicelles : a long lasting magnetically oriented biomembrane (UMR 5248 CBMN, Chimie et Biologie des Membranes et des Nanoobjets, Université Bordeaux 1, Pessac, France)

16:00-16:15 Hayet Bensikadour : Characterization of the interactions between fluoroquinolone antibiotics and lipids: Biophysical studies (Université Cathoique de Louvain, Brussels, Belgium)

16:15-16:30 Alicia Jacquemet : Supramolecular organization of archaeal lipid analogues at air/water interface (Université Européenne de Bretagne, Rennes, France)

16:40-17:05 Göran Lindblom : Lipid lateral diffusion and domain formation in bilayers studied by pfg-NMR (Department of Chemistry, Umea University, Umea, Suède)

17:05-17:30 Bukhard Bechinger : What about solid-state NMR investigations of polypeptide-lipid interactions (Membrane Biophysics and NMR Chemistry, University Louis Pasteur, Strasbourg, France)

17:30-17:55 Bruno Antonny : Recognition of membrane curvature by ALPS motifs (UMR-CNRS 6097 - Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France)

THURSDAY 23 OCTOBRE

SESSION 5 :
FROM DISEASES TO PREVENTION
(C. Forest and X. Collet)

8:30-8:55 Xavier Guillot : Plants producing Omega 3 fatty acids : specificities of the various vegetable sources, agro-environmental traits influencing their content (Laboulet Semences, Airaines, France)

8:55-9:20 Jean Dalongeville : N-3 fatty acids : Epidemiological evidence for fatal cardiovascular event prevention (Institut Pasteur, Lille, France)

9:20-9:45 Jean-Claude Mazière : Protective effect of n-3 polyunsaturated fatty acids against cardiovascular diseases: cellular and molecular aspects (CHU, Amiens, France)

9:45-10:05 Isabelle Dugail : Involvement of caveolin-1 in the structural organization of adipocyte lipid droplets (Centre de Recherche des Cordeliers, Paris, France)

10:05-10:25 E. Boutet : Seipin deficiency alters fatty acids D9 desaturation and lipid droplet formation in Berardinelli-Seip cpngenital lipodystrophy (UPMC Université Paris 06, Paris, France)

10:50- 11:15 Philippe Bougnoux : Adjuvant dietary intervention with DHA and CLA for prevention of relapses after breast cancer treatment (Centre Henry S. Kaplan, Tours, France)

11:15- 11:40 Marc Poirot : Pharmalogical identification of the cholesterol- epoxide hydrolase (Institut Claudius Regaud, Toulouse, France)

11:40- 12:00 Sabrina Florent-Béchard : Neuroprotective properties of DHA and perspectives for Alzheimer's disease prevention (ENSAIA- INPL, Vandoeuvre-lès-Nancy, France)

14:15-14:40 Claude Forest : Do you need lipids? Make glycerol 3-phosphate (Université Paris Descartes, Paris, France)

14:40-14:55 Jean-Marc Blouin : Polyunsaturated fatty acids and thiazolidinediones induce expression of the cytosolic phosphoenolpyruvate carboxykinase gene in colon carcinoma Caco2 cells (Université Paris Descartes, Paris, France)

14:55-15:10 Mauro Antongiovanni : Does a sheep cheese, naturally rich in rumenic acid, have a beneficial influence on haematic lipid, inflammatory and rheological parameters ? (University of Florence, Florence, Italy)

15:10-15:35 Philip Calder: Polyunsaturated fatty acids and inflammatory processes - new twists in an old tale (University of Southampton, Southampton, UK)

16:05-16:35 Philippe Legrand : From alpha-linolenic fatty acids to DHA : the conversion pathway and its limits (INRA-Agrocampus Rennes)