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4th LIPIDOMICS MEETING 
TOULOUSE   9-11 October 2007

Hôtel de Région
22 Bd du Maréchal Juin, 31406 Toulouse

TUESDAY OCTOBER 9 - LIPOPROTEINS AND ATHEROSCLEROSIS

9:00-9:15 Welcome speach

Morning (Session 1)
Chairpersons : B.Perret, X.Collet

9:15-9:45 Opening session : Christopher FIELDING (San Francisco). Preb-HDL and reverse cholesterol transport

9:45-10:15 Philippe COSTET (Nantes) : Protease PCSK9, a new player in hypercholesterolemia

10:30-11:00 Coffee break and poster viewing

11:00-11:30 Laurent MARTINEZ (Toulouse) : The "F1-ATPase/P2Y13" HDL endocytosis pathway : a new paradigm ? Its role in cholesterol metabolism 

Oral presentations

11:30-11:45 Hepatic regulation of HDL endocytosis : the new pathway "ecto-F1-ATPase/P2Y13 purinergic receptor" implies the activation of Rho kinase I (ROCKI). C. Barbaras et al (Toulouse)
11:45-12:00 Gender specific differences in HDL particle profile are major determinants of celllular paathways for cholesterol efflux. Relative roles of ABCA1, ABCG1 and SR-BI.Catalano G. et al. (Paris)
12:00-12:15 Characterization of the role of PCSK9 in human intestine cells. C. Le May et al. (Nantes)
12:15-12:30 Scavenger receptor class B type I (SR-BI) and vitamin E transport. E. Reboul (Marseille) Gerli Thesis prize

GERLI Thesis prize "Scavenger receptor class B type I (SR-BI) and vitamin E transport"

12:30-15:00 Lunch and poster viewing

Afternoon (Session 2)  
Chairpersons : V.Clavey, J.F. Arnal

15:00-15:30 Jean-François ARNAL (Toulouse) : Oestrogens in vascular biology and disease - where do we stand today ?

15:30-16:00 Marc ISSANDOU (Les Ullis) : Assessing the role of stearoyl-CoA desaturase 1 in metabolic syndrome

16:00-16:30 Coffee break and poster viewing

Oral presentations

16:30-16:45 Estrogen receptor alpha (ERa) mediates the atheroprotective effect of 17b-estradiol. A. Billon et al. (Toulouse)
16:45-17:00 Over expression of caveolin-1 sensitizes vascular smooth muscle cells to oxidized LDL-induced apoptosis : involvement of TRPC1. C. Ingueneau et al. (Toulouse)

17:00-17:30 Anne TAILLEUX (Lille) :  PPAR alpha nuclear receptors and cardiovascular pathology

Welcome Buffet

WEDNESDAY OCTOBER 10- MEMBRANE LIPIDOMICS
Lipid domains, phosphoinositide kinases, new lipid messengers

Morning (Session 3) : Membrane organisation
Chairpersons : Bernard Payrastre, Michel Record

9:00-9:30 Gerrit van MEER (Utrecht) : Cellular lipidomics : lipid rafts and translocators in Golgi function

9:30-10:00 Hai-Tao HE (Marseille): Sphingolipid/cholesterol-dependent nanodomains in the plasma membrane of living cells : identification and roles in cell signalling

10:00-10:30 Sébastien MONGRAND (Bordeaux) : Putative role of plant lipid rafts in lipid signalling

10:30-11:00 Coffee break and poster viewing

11:00-11:30 Emmanuelle JEANNETTE (Paris) : Diacylglycerol Pyrophosphate (DGPP) : a new lipidic second messenger in plant signalling

Oral presentations

11:30-11:45 Myristic acid increases dihydroceramide D4-desaturase activity : influence of N-terminal myristoylation and subcellular targeting. E. Beauchamp et al. (Rennes)
11:45-12:00 Sphingolipid metabolites selectively elicit increases in nuclear calcium concentration in plant cells. P. Thuleau et al. (Castanet-Tolosan)
12:00-12:15 Selective decrease of bis-monoacylglycerophosphate (BMP) in macrophages by high supplementation with docosahexaenoic acid. J. Bouvier et al. (Lyon)
12:15-12:30 Cold-induced lipidic signalling in Arabidopsis thaliana. M.N. Vaultier (Ivry sur Seine) - GERLI Thesis prize

12:30-15:00 Lunch and poster viewing

Afternoon (Session 4) : Phosphoinositide specific Lipid kinases and phosphatases
Chairpersons : Martine Miquel, Alain Zachowski

15:00-15:30 Teun MUNNIK (Amsterdam) : Phospholipid signalling in plants - Similarities and differences to the mammalian paradigm

15:30-16:00 Nullin DIVECHA (Amsterdam): Phosphoinositide kinases in nucleus signalling

16:00-16:30 Coffee break and poster viewing

Oral presentations

16:30-16:45 Cardiolipin-rich domain formation induced by a peripheral mitochondrial protein. O. Maniti (Lyon)
16:45-17:00 Phosphatidylinositol 5-phosphate : a new lipid second messenger ? S. Coronas et al. (Toulouse)

17:00-17:30 Jocelyn LAPORTE (Strasbourg) : Phosphoinositide metabolism and neuromuscular diseases 

18:00-19:30 Private guided tour of Bemberg museum (please register)

20:00 Gala diner (please register)

THURSDAY OCTOBER 11
LIPID MEDIATORS AND RELATED PHYSIOPATHOLOGIES

Morning (Session 5)
Chairpersons : Jean-Sébastien Saulnier-Blache, Thierry Levade

9:00-9:30 Wounter MOOLENAAR (Amsterdam) : Regulation and biological activities of the autotaxin-LPA axis

9:30-10:00 Olivier PEYRUCHAUD (Lyon): LPA receptor and bone metastasis

Oral presentations

10:00-10:15 Targeting the LPA1 receptor attenuates renal interstitial fibrosis. J.P. Pradère et al. (Toulouse)
10:15-10:30 Role of lysophosphatidic acid in rat uterine leiomyoma cells. E. Billon-Denis et al. (Orsay)

10:30-11:00 Coffee break and poster viewing

11:00-11:15 FasL-triggered inhibition of sphingomyelin synthesis is involved in ceramide increase and caspase-dependent and independent cell death in human activated and leukemia T cells. D. Milhas et al. (Toulouse)
11:15-11:30 The exhaustive analysis of lipid hydroperoxydes in biological samples by LC-MSMS. T. Miyazawa et al. (Sendaï)
11:30-11:45 Modifications of cholesterol metabolism in brain following uranium contamination. R.A. Racine et al. (Fontenay aux Roses)
11:45-12:00 Inhibition mechanisms of hormone sensitive lipase and application in type 2 diabetes treatment. Y. Ben Ali (Marseille) Gerli Thesis prize

12:00-12:30 GERLI general assembly and attribution of thesis prizes

12:30-15:00 Lunch and poster viewing

Afternoon (Session 6)
Chairpersons : Claude Forest, Philippe Valet

15:00-15:30 P. van VELDHOVEN (Leuven) : A new lethal sphingolipidosis linked to sphingosine-1-phosphate signalling ?

Oral presentations

15:30-15:45 Up regulation of the Sphk-S1p axis in rat myometrium at the end of gestation is associated with an increased expression of cyclooxygenase 2. M. Serrano-Sanchez et al. (Orsay)
15:45-16:00 Phospholipids of HDL inhibit dendritic cell ability to stimulate the immune response. L. Perrin-Cocon et al. (Lyon)
16:00-16:15 Estrogen receptor-alpha dependent mechanisms accounting for the regenerative effect of estradiol on endothelium in vivo. C. Filipe et al. (Toulouse)

16:15-16:30 Coffee break and poster viewing

16:30-17:00 Paul GRIMALDI (Nice) : PPARs and metabolic syndrome 

17:00 CONCLUDING REMARKS