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Ces offres et/ou demandes sont à envoyer au secrétaire de l’association : email@example.com
Available PhD student position on Microalgal Carbon and Lipid Metabolism
Topic: Manipulating redox balance to increase carbon reserve formation in microalgae
Host lab: The lab is located at Institute of Bioscience and Biotechnology of Aix Marseille (http://biam.cea.fr/drf/biam/Pages/accueil.aspx), which is part of The French Atomic and Alternative Energy Commission (CEA), and part of the French National Center for Scientific Research (CNRS), and University of Aix Marseille in the region Provence in the South of France.
Starting date: fall 2019 (3 years)
Funding: This project is funded by the CEA. The PhD student will receive a very competitive stipends plus all the social benefit.
Director of Thesis: Dr. Yonghua Li-Beisson
Scientific background and project: Microalgae requires only sun light and water to fix atmosphere CO2 into organic carbon. They therefore represent a promising platform not only for production of a range of biomaterials ranging from food, fuel to green chemistry application, but also are key to achieving a carbon neutral economy. Microalgae naturally have the capacity to produce starch and lipids; starch are precursors to bioethanol and lipids are precursors to biodiesel. But high amount of starch or lipid is made mostly under conditions when cell division and growth are compromised. Our team has recently discovered for the first time that redox communication occur between peroxisome and chloroplast, two of the three most energetic subcellular organelles, and we further shown that this redox communication plays an important role in regulation of photosynthesis, lipid and starch metabolism (Kong et al 2018 Plant Cell). In this PhD thesis, we aim to further explore the impact of altering redox state on carbon reserve formation in microalgae.
Profile desired: The candidate is expected to have already some experience working with molecular biology of Chlamydomonas. Experience in Confocal microscopy a plus. He/she will be trained in algal physiology, lipidomics and metabolism. He/she will work in close collaboration with other researchers, technicians and students of the group.
Reference: Kong F, Burlacot A, Liang Y, Legeret B, Alseekh S, Brotman Y, Fernie AR, Krieger-Liszkay A, Beisson F, Peltier G, Li-Beisson Y (2018) Interorganelle Communication: Peroxisomal MALATE DEHYDROGENASE 2 Connects Lipid Catabolism to Photosynthesis through Redox Coupling in Chlamydomonas. Plant Cell
For more ref on related work : please visit the https://orcid.org/0000-0003-1064-1816
Postdoctoral associate position is available in the laboratory of Dr. Ondrej Kuda at the Institute of Physiology of the Czech Academy of Sciences (IPHYS) in Prague. IPHYS is a leading national institution in research on normal and pathological physiology. The mission of the Institute is to enhance fundamental knowledge of the processes involved in metabolic regulation and its impact on cardiovascular, neuronal and brain function.
We are looking for curious, imaginative, independent and highly-motivated applicants holding a PhD with experience in biochemistry/physiology/molecular biology. Skills in any of the following: bioinformatics/programing, whole animal physiology, LC-MS/MS are a plus. The institute is bilingual (Czech/English) and good communication skills and a collaborative attitude are important.
The focus of Dr. Kuda’s lab is the metabolism and regulatory actions of bioactive lipids, specifically as related to pathways of glucose and lipid metabolism. We are interested in products of de novo lipogenesis such as branched fatty acid esters of hydroxy fatty acids (FAHFA), in anti-inflammatory & pro-resolving eicosanoids and docosanoids, and in endocannabinoid-like metabolites derived from omega-3 polyunsaturated fatty acids. We combine cutting edge biochemical, bioinformatics and LC-MS-based omic approaches to elucidate pathway regulation and relevance to the mechanisms underlying metabolic diseases such as type 2 diabetes and obesity. For additional information see lab website: http://www.fgu.cas.cz/en/departments/metabolism-of-bioactive-lipids
The position is initially funded for 2 years with possibility of extension for up to 5 years. Starting date can be anytime in the first half of 2019. Dr. Kuda’s lab is well funded by national research grants and institutional support from the Czech Academy of Sciences. The position salary is competitive and exceeds average compensation for similar positions in the local metropolitan area.
Applications should be sent directly to Dr. Kuda at firstname.lastname@example.org before April 12th, 2019. Applications will not be reviewed until all below items are received. Applicants will be contacted to schedule an interview till April 12th.
1. Curriculum vitae
2. Two publications (attach PDFs). First author or with major contribution.
3. Cover letter: State why you qualify for the position and include description of relevant skills and experience
4. Copy of official diploma and any other academic records you wish to provide in support of your application
5. List of two to five references (with address and contact email) and indicate how these individuals are professionally related to you.
Post-doctoral position in Lipidomics
A postdoctoral researcher fellowship position (18 months) in lipidomics/sterolomics is available at ISA (ANABIO-MS team) in close collaboration with Ecotoxicolgy group (Irstea). The fellowship funded by the ANR will be starting in September 2019.
Aquatic ecosystems are exposed to environmental stressors such as chemical micropollutants from natural environment or anthropogenic activities. These chemical contaminations may result in alterations of the internal biochemical homeostasis of the aquatic organisms. The major limitation in the mechanistic knowledge of environmental chemical toxicity effects on aquatic organisms is the absence of molecular information notably at the genome wide scale in environmentally relevant species. The “omics” technologies – such as Transcriptomics, Proteomics, Lipidomics, Metabolomics – offer a great promises to help to elucidate molecular responses to exposures in aquatic organisms during specific and vulnerable life cycle stages. Lipid metabolism is the major fundamental metabolic pathway producing energy in animals. In fresh water organisms, lipids play a pivotal role in vulnerable stages like molting, reproduction, development. Recently, it has been shown that pharmaceutical drugs like hypolipidemic drugs have been detected in sewages, affecting the reproduction and population growth of crustacean amphipods (genus Gammarus). To understand and predict the effects of toxic exposures, it is crucial to describe the lipidome and to identify the affected metabolic networks. The project aim to gain a mechanistic understanding of toxic effects of hypolidiaemia drugs (statins and fibrates) on the sentinel organism, G. fossarum.
An innovative multi-omics approach (proteomics and lipidomics) will be developed to monitor metabolic perturbation on different development stages and reproductive cycles of G. fossarum after exposure with hypolidiaemia drugs.
For further details of the project, please follow the link : http://www.agence-nationale-recherche.fr/Project-ANR-18-CE34-0008
We seek a highly motivated and enthusiastic candidate with a PhD in the area of lipidomics with a focus on sterols analysis, or analytical chemistry or ecotoxicology with an interest in analytical chemistry.
The successful applicant will work at the Institute of Analytical Sciences (ANABIO-MS team) in collaboration with Ecotoxicology group at Irstea.
The requested skills include:
Strong chemical background with a PhD in Analytical Chemistry or Biochemistry with hands-on mass spectrometry
A significant level of technical knowledge and experience in mass spectrometry (Triple quadrupole, Q-TOF) including its applications in lipidomics or metabolomics
Experience in biological sample preparation techniques
Experience in chemometrics (intermediate to strong skills) and data mining will be an asset (R, Matlab).
Evidence of peer-reviewed publications
Good collaboration and communication skills (written and oral English)
Salary and appointments terms
The salary and appointment terms are consistent with the current rules for post-doctoral fellows. The period of employment is 18-months starting in September 2019.
The successful candidate is expected to start in September 2019. The closing date for applications is 15th May 2019. Applications must be submitted as a single PDF containing:
Current curriculum vitae including the list of publications
A cover letter
References (with letters of support)
Further information / contact
Sophie Ayciriex, PhD
Institute of Analytical Sciences (ISA),
CNRS UMR 5280 – ENS Lyon – University Claude Bernard Lyon 1
5 Rue de la Doua- 69100 Villeurbanne (France)
Dear Lipid Colleagues,
I am currently recruiting postdoc(s) to work on lipid metabolism at Brookhaven National Lab in New York. My lab comprises an active group of collaborative postdocs and professionals working on lipid metabolism. Lab members also interact synergistically with lipid groups led by Jorg Schwender and Changcheng Xu in the Biology department. The biology department at BNL is a great place for postdocs to develop new skills and exploit them to answer important open questions in lipid metabolism.
Details of the position and application can be found at:
Funding starts immediately, so successful candidate(s) could start as soon as they are available.
If you know of a good candidate who is about to graduate, or already looking for a postdoc position, please bring this to their attention.
Senior Biochemist and Chair of Biology,
Brookhaven National Lab.
Dear Reader, It is with great pleasure I invite you to Seville for the 2019 Euro Fed Lipid congress in Seville. We […]Read more
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