Offres d’emploi

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July 6, 2020 PhD

Study of the mechanisms of lipids oxidation and antioxidant in complex food matrices : Example of infant formulas enriched in polyunsaturated fatty acids

PhD Offer

Contract Type : 3 years Doctoral contract CIRAD/INRAE
Starting date : Last trimester 2020

Pierre Villeneuve

TA B-62 / 16
Maison de la Technologie / Bât 16
73 rue Jean-François Breton
34398 MONTPELLIER Cedex 05

Tel/Phone (33) (0)4 67 61 49 84

Study of the mechanisms of lipids oxidation and antioxidant in complex food matrices : Example of infant formulas enriched in polyunsaturated fatty acids

PhD Summary : Food products displaying high content in polyunsaturated fatty acids are crucial for infant nutrition but particularly susceptible to lipid oxidation. Such oxidative alteration leads to the degradation of the food product nutritionnal profile and to the potential formation of toxic compounds. In food matrices, lipids are most of the time found under dispersed form (it is also the case in powders) and their oxidative behaviour is very complex. Indeed, in such heterogeneous systems, oxidation occurs primarily at oil-water interface where pro-oxidant agents come into contact with oxidable substrate (lipid) and initiate the reaction. In this context, our previous studies on model emulsions (oil-in-water) have demonstrated the importance of using antioxidant molecules able to locate predominantly at interface to optimize their activity. Similarly, we have demonstrated the key role of other tensioactive substances (emulsifier, proteins…) which can act as traps for pro- or antioxidants in the system and modulate the kinetics of oxidation. However up to now the transport and diffusion of radicals within heterogeneous food matrices is not described. And yet, we are convinced that a better understanding of these dynamics of transfer between the various components of the food systems (micellar phase-interface-lipid susbstrate) would lead to a better stabilization of food systems enriched in polyunsaturated fatty acids. The objective of this thesis will be to elucidate the mechanisms of propagation of lipid oxidation whithin heterogeneous food products, taking unsaturated fatty acids enriched infant formulas as an example. We will first work on model emulsion systems mimicking these products to unveil the mechanims of diffusion of oxidation using confocal imaging with fluorescent probes reporter of oxidation or RAMAN imaging. Then we will study the influence of natural antioxidants or proteins, used either isolated, or associated under the form of natural assemblies (vesicles, membrane fragments…) on the modulation of oxidation kinetics and will model these kinetics. In a second part of the thesis, we will validate these results in a real set of food product: infant formula in powder form. We aim at demonstrating that formulation and potentially process modification of this food product can improve its resistance to oxidation and thus improve its nutritionnal properties during storage.

Lipid Composition and State of Oxidation of Fortified Infant Flours in Low-Income Countries Are Not Optimal and Strongly Affected by the Time of Storage. Moustiés C, Bourlieu C, Baréa B, Servent A, Alter P, Lebrun M, Hemery Y, Laillou A, Avallone S. Eur. J. Lipid Sci. Technol 2019.
The need for a new step in the study of lipids oxidation in heterophasic systems. Villeneuve P, Durand E, Decker EA. J. Agric. Food Chem. 2018.
Eleostearic Phospholipids as Probes to Evaluate Antioxidants Efficiency against Vesicles Liposomes Oxidation. Durand E, Delavault A, Bourlieu C, Lecomte J, Figueroa M, Decker EA, Michel-Salaun F, Kergourlay G, Villeneuve P. Chem. Phys. Lipids. 2017.
A Comparison of Antioxidant Evaluation Assays for Investigating Antioxidative Activity of Gallic Acid and Its Alkyl Esters in Different Food Matrices. Phonsatta N, Deetae P, Luangpituksa P, Grajeda Iglesias C, Figueroa-Espinoza MC, Lecomte J, Villeneuve P, Decker EA, Visessanguan W, Panya A. J. Agric. Food Chem. 2017.
Hurdles in Predicting Antioxidant Efficacy in Oil-in-Water Emulsions. Decker EA, Mc Clements DJ, Bourlieu-Lacanal C, Durand E, Figueroa-Espinoza MC, Lecomte J, Villeneuve P. Trends Food Sci. Technol. 2017.
Supervisors :
Doctoral School : GAIA (N°584), Montpellier, France
The PhD candidate will work in two Joint Research Units (UMR Qualisud and UMR IATE), both located in Montpellier, France.

General Requirements
Applicants should have a background in Chemistry, Food Chemistry, Nutrition. Good Knowledge of english. Highly motivated by research, autonomous, dynamic.

Candidacy must be sent to C. Bourlieu ( and P. Villeneuve ( and should contain :
– Curriculum
– Personal statement
– Letters of recommendation (2)
– Master grades

Contract Type : 3 years Doctoral contract CIRAD/INRAE
Starting date : Last trimester 2020

Pierre Villeneuve

TA B-62 / 16
Maison de la Technologie / Bât 16
73 rue Jean-François Breton
34398 MONTPELLIER Cedex 05

Tel/Phone (33) (0)4 67 61 49 84

July 6, 2020

The Bioscience and biotechnology Institute of Aix-Marseille (BIAM) is looking to recruit experienced and emerging scientific talents!

The Bioscience and biotechnology Institute of Aix-Marseille (BIAM) is looking to recruit experienced and emerging scientific talents!

Apply to the Call for International Mobility:

Situated in the south of France in the Provence-Alpes-Côte d’Azur, the BIAM is a joint research center between the Commissariat à l’énergie atomique et aux énergies alternatives (CEA), the Centre National de la Recherche Scientifique (CNRS) and Aix-Marseille Université.
The BIAM proposes an ambitious strategic and scientific project “Green solutions for tomorrow” that concentrates excellent fundamental, technological research and innovation by bringing together leading research teams and economic partners.
The project is organised around 2 fundamental research themes “energy bioconversion” and “the response and adaptation of living organisms to environmental constraints”
Apply to the Call for International Mobility:

As of the summer 2020, experienced scientists and talented early career researchers are invited to join BIAM to strengthen the Institute’s scientific project, either through mobility or appointment. Two permanent high-level researcher positions (PhD + a minimum of 2 years experience) are to be filled on the Cadarache site as part of the “Green solutions for tomorrow” project to reinforce existing teams or to promote transversality between exisiting themes.

Video about microalgae activities in the “Cité des Energies”
CEA Cadarache
DRF-BIAM Bât 177
13108 Saint-Paul-Lez-Durance

February 25, 2019 PhD student position

PhD student position on Microalgal Carbon and Lipid Metabolism

Available PhD student position on Microalgal Carbon and Lipid Metabolism


Topic: Manipulating redox balance to increase carbon reserve formation in microalgae

Host lab: The lab is located at Institute of Bioscience and Biotechnology of Aix Marseille (, which is part of The French Atomic and Alternative Energy Commission (CEA), and part of the French National Center for Scientific Research (CNRS), and University of Aix Marseille in the region Provence in the South of France.

Starting date: fall 2019 (3 years)

Funding: This project is funded by the CEA. The PhD student will receive a very competitive stipends plus all the social benefit.

Director of Thesis: Dr. Yonghua Li-Beisson


Scientific background and project: Microalgae requires only sun light and water to fix atmosphere CO2 into organic carbon. They therefore represent a promising platform not only for production of a range of biomaterials ranging from food, fuel to green chemistry application, but also are key to achieving a carbon neutral economy. Microalgae naturally have the capacity to produce starch and lipids; starch are precursors to bioethanol and lipids are precursors to biodiesel. But high amount of starch or lipid is made mostly under conditions when cell division and growth are compromised. Our team has recently discovered for the first time that redox communication occur between peroxisome and chloroplast, two of the three most energetic subcellular organelles, and we further shown that this redox communication plays an important role in regulation of photosynthesis, lipid and starch metabolism (Kong et al 2018 Plant Cell). In this PhD thesis, we aim to further explore the impact of altering redox state on carbon reserve formation in microalgae.

Profile desired: The candidate is expected to have already some experience working with molecular biology of Chlamydomonas. Experience in Confocal microscopy a plus. He/she will be trained in algal physiology, lipidomics and metabolism. He/she will work in close collaboration with other researchers, technicians and students of the group.

Reference: Kong F, Burlacot A, Liang Y, Legeret B, Alseekh S, Brotman Y, Fernie AR, Krieger-Liszkay A, Beisson F, Peltier G, Li-Beisson Y (2018) Interorganelle Communication: Peroxisomal MALATE DEHYDROGENASE 2 Connects Lipid Catabolism to Photosynthesis through Redox Coupling in Chlamydomonas. Plant Cell

For more ref on related work : please visit the




February 25, 2019 Post-Doctoral Associate Position (2-5 years) in Prague; Institute of Physiology

Research on Lipid Metabolism

Postdoctoral associate position is available in the laboratory of Dr. Ondrej Kuda at the Institute of Physiology of the Czech Academy of Sciences (IPHYS) in Prague. IPHYS is a leading national institution in research on normal and pathological physiology. The mission of the Institute is to enhance fundamental knowledge of the processes involved in metabolic regulation and its impact on cardiovascular, neuronal and brain function.
We are looking for curious, imaginative, independent and highly-motivated applicants holding a PhD with experience in biochemistry/physiology/molecular biology. Skills in any of the following: bioinformatics/programing, whole animal physiology, LC-MS/MS are a plus. The institute is bilingual (Czech/English) and good communication skills and a collaborative attitude are important.
The focus of Dr. Kuda’s lab is the metabolism and regulatory actions of bioactive lipids, specifically as related to pathways of glucose and lipid metabolism. We are interested in products of de novo lipogenesis such as branched fatty acid esters of hydroxy fatty acids (FAHFA), in anti-inflammatory & pro-resolving eicosanoids and docosanoids, and in endocannabinoid-like metabolites derived from omega-3 polyunsaturated fatty acids. We combine cutting edge biochemical, bioinformatics and LC-MS-based omic approaches to elucidate pathway regulation and relevance to the mechanisms underlying metabolic diseases such as type 2 diabetes and obesity. For additional information see lab website:
The position is initially funded for 2 years with possibility of extension for up to 5 years. Starting date can be anytime in the first half of 2019. Dr. Kuda’s lab is well funded by national research grants and institutional support from the Czech Academy of Sciences. The position salary is competitive and exceeds average compensation for similar positions in the local metropolitan area.
Applications should be sent directly to Dr. Kuda at before April 12th, 2019. Applications will not be reviewed until all below items are received. Applicants will be contacted to schedule an interview till April 12th.
1. Curriculum vitae
2. Two publications (attach PDFs). First author or with major contribution.
3. Cover letter: State why you qualify for the position and include description of relevant skills and experience
4. Copy of official diploma and any other academic records you wish to provide in support of your application
5. List of two to five references (with address and contact email) and indicate how these individuals are professionally related to you.

February 25, 2019 Post-doctoral position in Lipidomics

A postdoctoral researcher fellowship position (18 months) in lipidomics/sterolomics is available at ISA (ANABIO-MS team)

Post-doctoral position in Lipidomics
A postdoctoral researcher fellowship position (18 months) in lipidomics/sterolomics is available at ISA (ANABIO-MS team) in close collaboration with Ecotoxicolgy group (Irstea). The fellowship funded by the ANR will be starting in September 2019.
Aquatic ecosystems are exposed to environmental stressors such as chemical micropollutants from natural environment or anthropogenic activities. These chemical contaminations may result in alterations of the internal biochemical homeostasis of the aquatic organisms. The major limitation in the mechanistic knowledge of environmental chemical toxicity effects on aquatic organisms is the absence of molecular information notably at the genome wide scale in environmentally relevant species. The “omics” technologies – such as Transcriptomics, Proteomics, Lipidomics, Metabolomics – offer a great promises to help to elucidate molecular responses to exposures in aquatic organisms during specific and vulnerable life cycle stages. Lipid metabolism is the major fundamental metabolic pathway producing energy in animals. In fresh water organisms, lipids play a pivotal role in vulnerable stages like molting, reproduction, development. Recently, it has been shown that pharmaceutical drugs like hypolipidemic drugs have been detected in sewages, affecting the reproduction and population growth of crustacean amphipods (genus Gammarus). To understand and predict the effects of toxic exposures, it is crucial to describe the lipidome and to identify the affected metabolic networks. The project aim to gain a mechanistic understanding of toxic effects of hypolidiaemia drugs (statins and fibrates) on the sentinel organism, G. fossarum.
An innovative multi-omics approach (proteomics and lipidomics) will be developed to monitor metabolic perturbation on different development stages and reproductive cycles of G. fossarum after exposure with hypolidiaemia drugs.
For further details of the project, please follow the link :
We seek a highly motivated and enthusiastic candidate with a PhD in the area of lipidomics with a focus on sterols analysis, or analytical chemistry or ecotoxicology with an interest in analytical chemistry.
The successful applicant will work at the Institute of Analytical Sciences (ANABIO-MS team) in collaboration with Ecotoxicology group at Irstea.
The requested skills include:
 Strong chemical background with a PhD in Analytical Chemistry or Biochemistry with hands-on mass spectrometry
 A significant level of technical knowledge and experience in mass spectrometry (Triple quadrupole, Q-TOF) including its applications in lipidomics or metabolomics
 Experience in biological sample preparation techniques
 Experience in chemometrics (intermediate to strong skills) and data mining will be an asset (R, Matlab).
 Evidence of peer-reviewed publications
 Good collaboration and communication skills (written and oral English)
Salary and appointments terms
The salary and appointment terms are consistent with the current rules for post-doctoral fellows. The period of employment is 18-months starting in September 2019.
The successful candidate is expected to start in September 2019. The closing date for applications is 15th May 2019. Applications must be submitted as a single PDF containing:
 Current curriculum vitae including the list of publications
 A cover letter
 PhD diploma
 References (with letters of support)
Further information / contact
Sophie Ayciriex, PhD
Institute of Analytical Sciences (ISA),
CNRS UMR 5280 – ENS Lyon – University Claude Bernard Lyon 1
5 Rue de la Doua- 69100 Villeurbanne (France)

November 2, 2018 Post -Doc position on lipid metabolism

Postdoc(s) to work on lipid metabolism at Brookhaven National Lab in New York

Dear Lipid Colleagues,
I am currently recruiting postdoc(s) to work on lipid metabolism at Brookhaven National Lab in New York.   My lab comprises an active group of collaborative postdocs and professionals working on lipid metabolism.  Lab members also interact synergistically with lipid groups led by Jorg Schwender and Changcheng Xu in the Biology department.  The biology department at BNL is a great place for postdocs to develop new skills and exploit them to answer important open questions in lipid metabolism.
Details of the position and application can be found at:
Funding starts immediately, so successful candidate(s) could start as soon as they are available.
If you know of a good candidate who is about to graduate, or already looking for a postdoc position, please bring this to their attention.
John Shanklin
Senior Biochemist and Chair of Biology,
Brookhaven National Lab.

July 6, 2020 Projet de thèse




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